Triumphant
For this penultimate set of what I personnaly would define as the vintage era, there is, like for the last set, not that much to say. As explained in my introductory post on the HeartGold & SoulSilver Series, my estimate for the box ratios is 9.33 holos, 2.5 Pokémon LEGEND and 0.17 secret rares per box, as well as 5 Pokémon Prime (in the reverse slot). The rarity table looks as follows:
As can be seen, the pull rates for the Pokémon Prime (labelled SP for “special” in the table) are lower than in the previous two sets, and lower than in the HeartGold & SoulSilver base set, since there are 8 instead of 6 of them in the set and only 5 per box on average.
As to the holos, rares, Pokémon LEGEND and Pokémon Prime, the observed pulls from a (small-ish) Youtube sample are shown bellow - the dashed lines indicating where the transition from H11 to H10, etc., would occur:


I see no indication of artificial rarity differences.
As to the reverses, I compared the observed pulls (from a sub-sample of 4 boxes) with a model (labeled model 1) in which all 30 commons an 1 uncommon appear twice on the sheet (see below):
It doesn’t fit that well, so I am inclined to think that the RE2 cards are a mixture of reverse commons and reverse uncommons, but I can’t say anything for sure.
Edit 2023/09/09: Changed sheet size of Pokémon Prime to 10x11 (see introductory post on HeartGold & SoulSilver Series above)
Edit 2023/11/19: Changed sheet size of Pokémon Prime in model to 10x10 (see introductory post)